Document Detail

Activity of the antimicrobial polypeptide piscidin 2 against fish ectoparasites.
MedLine Citation:
PMID:  18471098     Owner:  NLM     Status:  MEDLINE    
Abstract The antiparasitic effects of piscidin 2, an antimicrobial polypeptide (AMPP) first isolated from mast cells of hybrid striped bass, were tested against three protistan ectoparasites of marine fish (the ciliates Cryptocaryon irritans and Trichodina sp., and the dinoflagellate Amyloodinium ocellatum) and one ciliate ectoparasite of freshwater fish (Ichthyophthirius multifiliis). I. multifiliis was the most susceptible parasite, with all theronts killed at 6.3 microg mL(-1) piscidin 2. The most resistant parasite was Trichodina, where a few cells were killed at 12.5 microg mL(-1), but several were still alive even at 100 microg mL(-1). C. irritans was of intermediate sensitivity, with some theronts killed at 12.5 microg mL(-1) and all killed at 25 microg mL(-1). High parasite density apparently exhausted the piscidin 2 before it could attain its maximal effect, but surviving parasites were often visibly damaged. The lower efficacy of piscidin 2 against marine parasites compared with the freshwater ciliate might be related to the inhibitory effects of high sea water cation levels. The tissue concentration of piscidins estimated in healthy hybrid striped bass gill (40 microg mL(-1)) suggests that piscidin 2 is lethal to the parasites tested at physiological concentrations and is thus an important component of innate defence in fish expressing this type of AMPP.
A Colorni; A Ullal; G Heinisch; E J Noga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of fish diseases     Volume:  31     ISSN:  0140-7775     ISO Abbreviation:  J. Fish Dis.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9881188     Medline TA:  J Fish Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-32     Citation Subset:  IM    
Israel Oceanographic and Limnological Research, National Center for Mariculture, Eilat, Israel.
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MeSH Terms
Antimicrobial Cationic Peptides / pharmacology*,  therapeutic use
Bass / parasitology
Ciliophora / drug effects*,  growth & development,  physiology
Ectoparasitic Infestations / drug therapy,  parasitology,  veterinary*
Fish Diseases / drug therapy,  parasitology*
Fish Proteins / pharmacology*,  therapeutic use
Gills / chemistry,  parasitology
Parasitic Sensitivity Tests
Survival Analysis
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Fish Proteins; 0/moronecidin protein, Morone saxatilis

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