Document Detail


Activity of antibiotic admixtures subjected to different freeze-thaw treatments.
MedLine Citation:
PMID:  10247478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The freezing of antibiotic admixtures has been proposed as a potentially useful method by which the efficiency of admixture services might be improved. The time involved in thawing, however, has discouraged the implementation of this practice. This study describes a technique of thawing frozen antibiotic admixtures contained in minibags in commercially available microwave ovens. A quantitative microbiological agar gel diffusion assay was employed to determine the effect of such treatment on the antibiotic activity of the admixture. Admixtures containing cephalothin sodium, cefazolin sodium, cefamandole nafate, cefoxitin sodium, penicillin G potassium, ampicillin sodium, oxacillin sodium, carbenicillin disodium, and gentamicin sulfate in dextrose 5% solution were frozen at -20 degrees C for 30 days. The admixtures were assayed immediately before freezing, and again after either thawing technique: that is, upon exposure of the minibags to room temperature air or to microwave radiation. Assays were also performed 8 and 24 hours after thawing in order to assess antibiotic stability following each freeze-thaw treatment. It was discovered that, with the exception of ampicillin sodium, each of the antibiotics studied could be frozen and thawed as described without significant loss of activity, and were stable for 24 hours after thawing. The application of a freeze microwave-thaw technique to central admixture services can be seen as a cost-effective method of circumventing many of the problems associated with existing programs.
Authors:
C J Holmes; R K Ausman; C W Walter; R B Kundsin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug intelligence & clinical pharmacy     Volume:  14     ISSN:  0012-6578     ISO Abbreviation:  Drug Intell Clin Pharm     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0212457     Medline TA:  Drug Intell Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  H    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / analysis
Boston
Drug Compounding / economics*
Drug Stability*
Freezing*
Humans
Infusions, Parenteral*
Microwaves
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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