Document Detail


Activity of T-Helper Cells in Patients with Primary Sjogren's Syndrome.
MedLine Citation:
PMID:  23422488     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PATIENTS AND METHODS: Peripheral blood mononuclear cells from 34 pSS, 13 nSS patients and 13 healthy controls were stimulated, labeled for cluster of differentiation-4 (CD4), interferon-γ (IFN-γ), interleukin-4 (IL-4) and IL-17A and analyzed by flow cytometry.
RESULTS: The activities of Th1 and Th17 cells in patients with pSS were similar to those of the control group. The percentage of both IFN-γ- and IL-17-producing Th17/Th1-like cells was significantly higher in the pSS, as compared to the control group, whereas that of Th2 cells was lower. A significant correlation was found between all Th-subset activities in the control group. However, in the pSS group, a correlation was found only between Th1 with Th2 and Th17 and Th17 with Th17/Th1-like.
CONCLUSION: The imbalance in Th-subset activities in peripheral blood may play a role in the pathogenesis of pSS.
Authors:
Gintaras Sudzius; Diana Mieliauskaite; Irena Butrimiene; Almantas Siaurys; Zygmunt Mackiewicz; Irena Dumalakiene
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  IM    
Affiliation:
State Research Institute Center for Innovative Medicine, Moletu str. 29, LT-08409, Vilnius, Lithuania. i.dumalakiene@imcentras.lt.
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