Document Detail


The activity of matrix metalloproteinase-9 is part of the mechanism of cell-to-cell HIV-1 endocytosis in dendritic cells.
MedLine Citation:
PMID:  21190541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV) starts to replicate upon virus-cell fusion mediated by the CD4-Env-coreceptor interaction. HIV enters target cells also through endocytosis, a mechanism which rarely leads to HIV replication. Both modes of entry are greatly improved by cell-cell contact. We recently reported that the contact of human primary dendritic cells with HIV-1 infected cells leads to high levels of virus endocytosis and HIV-1 antigen presentation activity in dendritic cells. Here, we provide evidence that the activity of matrix metalloproteinase (MMP)-9 is involved in the mechanism of cell-to-cell HIV-1 endocytosis in DCs. Accordingly, the specific inhibition of MMP-9 led to reduced extents of HIV-1 antigen presentation activity. The identification of cell molecules involved in the cell-to-cell HIV-1 endocytosis would be of significance for better understanding the mechanisms underlying the induction of the anti-HIV adaptive immune response.
Authors:
Eliana Ruggiero; Elena Toschi; Maurizio Federico
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current drug discovery technologies     Volume:  8     ISSN:  1875-6220     ISO Abbreviation:  Curr Drug Discov Technol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-16     Completed Date:  2011-09-06     Revised Date:  2012-04-05    
Medline Journal Info:
Nlm Unique ID:  101157212     Medline TA:  Curr Drug Discov Technol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  112-8     Citation Subset:  IM    
Affiliation:
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Adult
Anti-HIV Agents / pharmacology
Antigen Presentation
Cell Communication
Coculture Techniques
Dendritic Cells / drug effects,  enzymology*,  immunology,  virology*
Endocytosis* / drug effects
HIV Antigens / immunology
HIV-1 / drug effects,  growth & development,  immunology,  pathogenicity*
Humans
Male
Matrix Metalloproteinase 9 / antagonists & inhibitors,  genetics,  metabolism*
Protease Inhibitors / pharmacology
RNA Interference
U937 Cells
Virus Replication
Young Adult
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Antigens; 0/Protease Inhibitors; EC 3.4.24.35/Matrix Metalloproteinase 9

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