| The Activity and Localization of 3β-hydroxysteroid Dehydrogenase/Δ(5)-Δ(4) Isomerase and Release of Androstenedione and Progesterone by Uterine Tissues During Early Pregnancy and the Estrous Cycle in Pigs. | |
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MedLine Citation:
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PMID: 23095516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Steroid hormones are produced by the porcine uterus. We hypothesized that the uterus in pigs possesses active 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. In this study, we examined 1) endometrial and myometrial expression of 3β-HSD mRNA, 2) uterine 3β-HSD protein activity and 3) in vitro production of A(4) and P(4) by uterine slices harvested from pigs on days 10 to 11, 12 to 13 and 15 to 16 of pregnancy and the estrous cycle. The expression of 3β-HSD and the presence and activity of 3β-HSD protein were different in the endometrium and the myometrium during the examined periods of pregnancy and the estrous cycle. Production of A(4) by the endometrium and myometrium was highest on days 12 to 13 of pregnancy and the estrous cycle. Endometrial secretion of P(4) did not differ in the course of early pregnancy and on the respective days of the estrous cycle. The gravid myometrium was the highest source of P(4) in pregnant pigs on days 12 to 13. The release of P(4) by the cyclic myometrium rose during the examined days of the estrous cycle. The steroidogenic activity of the uterus, as described in this study, may support early pregnancy or the luteal phase of the estrous cycle in pigs. |
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Authors:
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Bartosz Wojciechowicz; Genowefa Kotwica; Justyna Kolakowska; Anita Franczak |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-25 |
Journal Detail:
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Title: The Journal of reproduction and development Volume: - ISSN: 1348-4400 ISO Abbreviation: J. Reprod. Dev. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438792 Medline TA: J Reprod Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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