Document Detail


Activity of DSA against anaerobically adapted Mycobacterium bovis BCG in vitro.
MedLine Citation:
PMID:  19520609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DSA is a beta-sulfonylacetamide with in vitro activity against pathogenic mycobacteria. Although the enzymatic target(s) of DSA has not been identified, studies to date suggest that this class of compounds may interfere directly or indirectly with ATP synthase and other components of the mycobacterial respiratory chain. In this study we further evaluated the in vitro activity of DSA against anaerobically adapted BCG using two established models. DSA killed BCG in the anaerobic Wayne model. Bactericidal activity ranged from >99% to 60%. DSA killed rifampin-tolerant persisters with a reduction in viable counts of 1.5log(10) versus controls. Conclusive identification of the DSA-specific target(s) will permit a better understanding of the unique mechanism of action of this class of compounds against both aerobically growing and anaerobically adapted bacilli in vitro.
Authors:
Nicole M Parrish; Chiew G Ko; James D Dick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-10
Journal Detail:
Title:  Tuberculosis (Edinburgh, Scotland)     Volume:  89     ISSN:  1873-281X     ISO Abbreviation:  Tuberculosis (Edinb)     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971555     Medline TA:  Tuberculosis (Edinb)     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  325-7     Citation Subset:  IM    
Affiliation:
Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. nparrish@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Anaerobiosis
Antitubercular Agents / pharmacology*
Mycobacterium bovis / drug effects*,  growth & development
Sulfonamides / pharmacology*
Grant Support
ID/Acronym/Agency:
AI43846/AI/NIAID NIH HHS; U01 AI054842-05/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Sulfonamides; 0/n-decanesulfonylacetamide
Comments/Corrections

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