| Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells. | |
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MedLine Citation:
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PMID: 22807337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed. |
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Authors:
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Lalit Kumar Sharma; Na-Ra Lee; Eun Ryoung Jang; Beilei Lei; Chang-Guo Zhan; Wooin Lee; Kyung-Bo Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-07-17 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: 13 ISSN: 1439-7633 ISO Abbreviation: Chembiochem Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-29 Completed Date: 2013-01-10 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: Germany |
Other Details:
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Languages: eng Pagination: 1899-903 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Binding Sites Cell Line Cell Line, Tumor Fluorescent Dyes / analysis*, chemistry Humans Microscopy, Fluorescence Molecular Docking Simulation Proteasome Endopeptidase Complex / analysis*, immunology Proteomics / methods |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA128903/CA/NCI NIH HHS; R15 CA156601/CA/NCI NIH HHS; RC1 MH088480/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; EC 3.4.25.1/LMP7 protein; EC 3.4.25.1/Proteasome Endopeptidase Complex |
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