Document Detail


Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.
MedLine Citation:
PMID:  22807337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.
Authors:
Lalit Kumar Sharma; Na-Ra Lee; Eun Ryoung Jang; Beilei Lei; Chang-Guo Zhan; Wooin Lee; Kyung-Bo Kim
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-17
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  13     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-29     Completed Date:  2013-01-10     Revised Date:  2013-09-19    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1899-903     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
Cell Line
Cell Line, Tumor
Fluorescent Dyes / analysis*,  chemistry
Humans
Microscopy, Fluorescence
Molecular Docking Simulation
Proteasome Endopeptidase Complex / analysis*,  immunology
Proteomics / methods
Grant Support
ID/Acronym/Agency:
R01 CA128903/CA/NCI NIH HHS; R01 CA128903/CA/NCI NIH HHS; R15 CA156601/CA/NCI NIH HHS; RC1 MH088480/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; EC 3.4.25.1/LMP7 protein; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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