Document Detail

Activities of purine metabolising enzymes in lymphocytes of neonates and young children: correlates with immune function.
MedLine Citation:
PMID:  3114134     Owner:  NLM     Status:  MEDLINE    
Depressed activities of the following purine enzymes have been shown to result in immunodeficiencies: adenosine deaminase (ADA), hypoxanthine-guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP). These enzymes and adenosine kinase (AK) were measured in cord blood lymphocytes of premature and small-for-gestational age infants since they have partial immunodeficiencies of unknown biochemical etiology which can persist for many years. We also measured these enzymes in 3 infants with various immunodeficiencies. Activities were compared with appropriate matched control groups. The results indicated normal ADA and PNP but significantly depressed AK (P less than 0.05) and HGPRT (P less than 0.001) activities in 10 premature/SGA infants when compared to 35 full-term normal infants. In the 3 immunodeficient children the results were as follows: Child 1 had a 2- to 3-fold decrease in ADA with normal PNP and AK activities; Child 2 had a 2- to 3-fold decrease in AK, 4-fold decrease in HGPRT with normal PNP and ADA activities; Child 3 had confirmed AIDS and a 4-fold decrease in ADA, 6-fold decrease in HGPRT with normal PNP activity. The possible role of these depressed purine enzyme activities found in lymphocytes is discussed in relation to the imparied immunity seen in these infants.
J A Renouf; Y H Thong; A H Chalmers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  15     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
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MeSH Terms
Adenosine Deaminase / blood
Adenosine Kinase / blood
Age Factors
Child, Preschool
Fetal Blood / enzymology
Hypoxanthine Phosphoribosyltransferase / blood
Immunologic Deficiency Syndromes / etiology,  metabolism*
Infant, Newborn
Lymphocytes / immunology,  metabolism*
Purine-Nucleoside Phosphorylase / blood
Purines / metabolism*
Reg. No./Substance:
0/Purines; EC Phosphorylase; EC Phosphoribosyltransferase; EC Kinase; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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