| Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures. | |
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MedLine Citation:
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PMID: 205362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activities of pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), and glycogen synthetase (GS) were determined in the cancerous and in the apparently uninvolved (host) regions of livers from primary hepatoma patients as well as in normal adult human livers and human fetal livers. The activities of these enzymes were also assayed in a fairly fast-growing, 3'-methyl-4-dimethylaminoazobenzene-induced transplantable rat hepatoma and in hepatoma cell lines derived from both rat and human tumors. In the human hepatoma, as in the rat hepatoma, the activities of PC, PEPCK, and G6Pase were considerably reduced, compared to those in the host liver. The activities of both the a (glucose 6-phosphate-independent) and b (glucose 6-phosphate-dependent) forms of GS were also lower in human and rat hepatomas than in the respective host livers. Activities of PC, PEPCK, and G6Pase in the human hepatomas were often comparable with those of fetal livers. In rat and human hepatoma cells, the activities of PC, PEPCK, and G6Pase were similar to or lower than the activities in the respective hepatomas; the activities of GS a were also similar to those in the hepatoma, whereas the activities of GS b were somewhat higher. |
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Authors:
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K D Hammond; D Balinsky |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cancer research Volume: 38 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-06-17 Completed Date: 1978-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1317-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / metabolism* Cells, Cultured Fetus / metabolism Gluconeogenesis* Glucose-6-Phosphatase / metabolism Glycogen Synthase / metabolism* Humans Liver / metabolism* Liver Neoplasms / metabolism* Neoplasms, Experimental / metabolism Phosphoenolpyruvate Carboxykinase (GTP) / metabolism Pyruvate Carboxylase / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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EC 2.4.1.11/Glycogen Synthase; EC 3.1.3.9/Glucose-6-Phosphatase; EC 4.1.1.32/Phosphoenolpyruvate Carboxykinase (GTP); EC 6.4.1.1/Pyruvate Carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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