Document Detail


Activities of hepatic enzymes in spontaneous diabetes rats produced by selective breeding of normal Wistar rats.
MedLine Citation:
PMID:  151947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acitivites of the hepatic enzymes were determined in spontaneous diabetes rats. The activities of the enzymes were compared with those in normal rats and in streptozotocin diabetic rats. In the spontaneous diabetes rats, glycogen phosphorylase and glycogen synthase were 14.6 +/- 0.6 and 1.73 +/- 0.15 U respectively. The activities of both the enzymes were significantly increased. In the spontaneous diabetes rats glucokinase was 3.82 +/- 0.5 U showing a significant increase. On the contrary, the activity of the enzyme was decreased in the streptozotocin diabetic rats. Glucose-6-phosphatase was increased both in the spontaneous diabetes rats and in the streptozotocin diabetic rats. Fructose-1,6-diphosphatase was increased in the spontaneous diabetes rats. Glucose-6-phosphate dehydrogenase was increased in the spontaneous diabetes rats and decreased in the streptozotocin diabetic rats. In the spontaneous diabetes rats phosphofructokinase showed a reduction of the activity and glucose-6-phosphate dehydrogenase was elevated. These findings are consistent with the results of activities of the hepatic enzymes in adult-onset diabetic patients. These patterns of the hepatic enzymes in the spontaneous diabetes rats were different from those in the streptozotocin diabetic rats. From these patterns of activities of the hepatic enzymes, the spontaneous diabetes rats produced by repetition of selective breeding according to Goto et al. (1975,1976) are an excellent model of human adult-onset diabetes.
Authors:
A Kitahara; T Toyota; M Kakizaki; Y Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  126     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / enzymology*
Glucosephosphate Dehydrogenase / metabolism
Glycogen / metabolism
Glycogen Synthase / metabolism*
Liver / enzymology*
Male
Phosphorylases / metabolism*
Rats
Rats, Inbred Strains
Streptozocin
Chemical
Reg. No./Substance:
18883-66-4/Streptozocin; 9005-79-2/Glycogen; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.4.1.-/Phosphorylases; EC 2.4.1.11/Glycogen Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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