Document Detail

Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.
MedLine Citation:
PMID:  7861246     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine how food restriction (40% restriction of food intake) altered the age-related changes in the activities of Cu,Zn superoxide dismutase, catalase and glutathione peroxidase in liver, brain cortex, heart, kidney and intestinal mucosa obtained from 6-, 16- and 26-mo-old male Fischer 344 rats. Food restriction increased the activity of one or more of the antioxidant enzymes in the liver, brain cortex, heart and kidney of the rats. However, the magnitude of the effect and the antioxidant enzyme(s) affected by food restriction varied from tissue to tissue, and food restriction had no significant effect on the activities of these enzymes in intestinal mucosa. Interestingly, the four tissues in which food restriction increased the activity of one or more of the antioxidant enzymes showed reduced lipid peroxidation as measured by thiobarbituric acid-reactive material. These data suggest that food restriction might enhance the survival of rodents by altering the levels of the antioxidant enzymes and hence reducing free radical damage.
E Xia; G Rao; H Van Remmen; A R Heydari; A Richardson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  125     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-21     Completed Date:  1995-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-201     Citation Subset:  IM    
Geriatric Research, Education and Clinical Center, Audie L. Murphy Memorial Veterans Hospital, San Antonio, TX.
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MeSH Terms
Aging / metabolism
Antioxidants / analysis*
Catalase / analysis*,  physiology
Cerebral Cortex / enzymology
Food Deprivation / physiology*
Glutathione Peroxidase / analysis*,  physiology
Intestinal Mucosa / enzymology
Kidney / enzymology
Lipid Peroxidation
Liver / enzymology
Myocardium / enzymology
Rats, Inbred F344
Superoxide Dismutase / analysis*,  physiology
Grant Support
Reg. No./Substance:
0/Antioxidants; EC; EC Peroxidase; EC Dismutase

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