Document Detail


Activities of antioxidant enzymes in muscle, liver and lung of chickens with inherited muscular dystrophy.
MedLine Citation:
PMID:  3947339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An inherited form of muscular dystrophy in chickens has been used as a model of Duchenne muscular dystrophy. The pectoralis major muscle of chickens with this disease showed a significantly elevated activity of catalase (CAT) one day after hatching, and by 7 days showed elevated superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) activities. Increases were also found in tissues of the dystrophic birds that, unlike the pectoralis muscle, are considered to be unaffected by the pathology of muscular dystrophy. The soleus muscle contained significantly increased levels of SOD and GPX in 1 and 7 day old chickens, and increased GST in 1, 14, and 28 day old birds. CAT was significantly increased in liver from 1 and 7 day old chickens, while GPX was increased in lung from 1, 7 and 14 day old birds. These results support the possibility that excess oxygen free-radicals or altered cellular antioxidant defenses play some role in the pathogenesis of muscular dystrophy.
Authors:
M E Murphy; J P Kehrer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  134     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-24     Completed Date:  1986-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  550-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalase / metabolism*
Chickens
Glutathione Peroxidase / metabolism*
Glutathione Transferase / metabolism*
Liver / enzymology
Lung / enzymology
Muscles / enzymology
Muscular Dystrophies / enzymology*
Superoxide Dismutase / metabolism*
Grant Support
ID/Acronym/Agency:
HL01435/HL/NHLBI NIH HHS; RR05849/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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