Document Detail


Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary.
MedLine Citation:
PMID:  19481739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Germ cell-expressed activin A promotes germ cell survival and proliferation indirectly, possibly by maintaining ovarian pregranulosa cells in an undifferentiated state and preventing primordial follicle formation until oocytes have matured sufficiently. We have previously demonstrated that recombinant activin A can repress the expression of Kit ligand (KITLG) in cultures of human fetal ovaries, and here we extend this finding to show that this repression acts selectively on the membrane-bound isoform of Kit ligand without affecting the soluble form, providing a potential mechanism for suppressing direct interaction between somatic and germ cells and thus inhibiting precocious primordial follicle formation.
Authors:
Andrew J Childs; Richard A Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-29
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-11-03     Revised Date:  2013-04-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1416-9     Citation Subset:  IM    
Affiliation:
Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Activins / pharmacology*
Cells, Cultured
Down-Regulation / drug effects,  genetics
Female
Fetus / drug effects*,  metabolism
Gene Expression Regulation, Developmental / drug effects
Gestational Age
Humans
Membrane Proteins / genetics,  metabolism
Models, Biological
Ovary / drug effects*,  embryology*,  metabolism
Protein Isoforms / genetics,  metabolism
Stem Cell Factor / genetics*,  metabolism
Substrate Specificity
Grant Support
ID/Acronym/Agency:
MC_U127684439//Medical Research Council; U.1276.00.002.00001.01(61015)//Medical Research Council; WBS U.1276.00.002.00001.01//Medical Research Council
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/Protein Isoforms; 0/Stem Cell Factor; 0/activin A; 104625-48-1/Activins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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