Document Detail


Active transposition in genomes.
MedLine Citation:
PMID:  23145912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transposons are DNA sequences capable of moving in genomes. Early evidence showed their accumulation in many species and suggested their continued activity in at least isolated organisms. In the past decade, with the development of various genomic technologies, it has become abundantly clear that ongoing activity is the rule rather than the exception. Active transposons of various classes are observed throughout plants and animals, including humans. They continue to create new insertions, have an enormous variety of structural and functional impact on genes and genomes, and play important roles in genome evolution. Transposon activities have been identified and measured by employing various strategies. Here, we summarize evidence of current transposon activity in various plant and animal genomes.
Authors:
Cheng Ran Lisa Huang; Kathleen H Burns; Jef D Boeke
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of genetics     Volume:  46     ISSN:  1545-2948     ISO Abbreviation:  Annu. Rev. Genet.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-13     Completed Date:  2013-04-22     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0117605     Medline TA:  Annu Rev Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  651-75     Citation Subset:  IM    
Affiliation:
Institute of Genetic Medicine and High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. chuang36@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Arabidopsis / genetics
DNA Transposable Elements*
Evolution, Molecular
Gene Frequency
Genetic Variation
Genome, Human
Genome, Plant*
Humans
Long Interspersed Nucleotide Elements
Mutagenesis, Insertional / genetics*
Phenotype
Selection, Genetic
Short Interspersed Nucleotide Elements
Transformation, Genetic*
Grant Support
ID/Acronym/Agency:
P30 CA006973/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA Transposable Elements
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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