Document Detail

Active tissue factor and activated factor XI in circulating blood of patients with systolic heart failure due to ischemic cardiomyopathy.
MedLine Citation:
PMID:  20864906     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Elevated clotting factors and thrombin generation have been reported to occur in patients with heart failure (HF). Circulating activated factor XI (FXIa) and active tissue factor (TF) can be detected in acute coronary syndromes and stable angina.
OBJECTIVES: We investigated circulating FXIa and active TF and their associations in patients with systolic HF due to ischemic cardiomyopathy.
PATIENTS AND METHODS: In an observational study, we assessed 53 consecutive patients, aged below 75 years, with stable HF associated with documented coronary artery disease (CAD). Atrial fibrillation, recent thromboembolic events, and current anticoagulant therapy were the exclusion criteria. Plasma TF and FXIa activity was determined in clotting assays by measuring the response to inhibitory monoclonal antibodies.
RESULTS: Coagulant TF activity was detected in 20 patients (37.7%), and FXIa in 22 patients (41.5%). Patients with detectable TF activity and/or FXIa were younger, had a history of myocardial infarction more frequently, significantly higher F1+2 prothrombin fragments, larger left atrium (LA) and right ventricular diastolic diameter, and higher right ventricular systolic pressure than the remaining subjects (P ≤ 0.01 for all). Circulating FXIa was positively correlated with F1+2 levels (r = 0.69; P < 0.001).
CONCLUSIONS: Circulating active TF and FXIa occurred in about 40% of patients with systolic HF due to ischemic cardiomyopathy. The presence of these factors was associated with enhanced thrombin formation. Associations between both factors and LA diameter and right ventricular parameters might suggest that TF and FXIa predispose to thromboembolic complications of HF.
Michał Zabczyk; Saulius Butenas; Ilona Palka; Jadwiga Nessler; Anetta Undas
Related Documents :
3613006 - Occupation and risk of death from coronary heart disease.
3336396 - Type a behavior and mortality from coronary heart disease.
19626396 - Presence of irregularity in region between -1115 and -784 nt in p1 promoter of insulin-...
2607526 - An integrated view of hypertension.
3613006 - Occupation and risk of death from coronary heart disease.
22278106 - Approach to assessing myocardial perfusion in rats using static [13n]-ammonia images an...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnętrznej     Volume:  120     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-18     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  334-40     Citation Subset:  IM    
Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Blood Coagulation
Blood Coagulation Tests
Cardiomyopathies / blood*,  complications
Factor XIa / metabolism*
Factor Xa / metabolism*
Heart Failure, Systolic / blood*,  drug therapy,  etiology
Middle Aged
Myocardial Infarction / blood*,  complications
Grant Support
Reg. No./Substance:
0/Biological Markers; EC XIa; EC Xa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  3ST-POL trial: standards of statin use in Poland in the context of the European Society of Cardiolog...
Next Document:  A summary of recent recommendations on the management of patients with nonvariceal upper gastrointes...