Document Detail

Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles.
MedLine Citation:
PMID:  20936240     Owner:  NLM     Status:  MEDLINE    
Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (>80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 μg ml(-1) for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates.
Yiwei Teow; Suresh Valiyaveettil
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-11
Journal Detail:
Title:  Nanoscale     Volume:  2     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2011-03-21     Revised Date:  2011-06-22    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  2607-13     Citation Subset:  IM    
Department of Chemistry, National University of Singapore (NUS), 3 Science Drive 3, 117543, Singapore.
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MeSH Terms
Antineoplastic Agents / administration & dosage,  chemistry*,  toxicity
Cell Line, Tumor
Drug Carriers / chemistry*
Folic Acid / chemistry*
Metal Nanoparticles / chemistry*,  toxicity
Microscopy, Confocal
Platinum / chemistry*
Povidone / chemistry
Reg. No./Substance:
0/Antineoplastic Agents; 0/Drug Carriers; 59-30-3/Folic Acid; 7440-06-4/Platinum; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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