| Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles. | |
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MedLine Citation:
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PMID: 20936240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (>80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 μg ml(-1) for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates. |
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Authors:
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Yiwei Teow; Suresh Valiyaveettil |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-11 |
Journal Detail:
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Title: Nanoscale Volume: 2 ISSN: 2040-3372 ISO Abbreviation: Nanoscale Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-03-21 Revised Date: 2011-06-22 |
Medline Journal Info:
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Nlm Unique ID: 101525249 Medline TA: Nanoscale Country: England |
Other Details:
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Languages: eng Pagination: 2607-13 Citation Subset: IM |
Affiliation:
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Department of Chemistry, National University of Singapore (NUS), 3 Science Drive 3, 117543, Singapore. chmsv@nus.edu.sg. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage,
chemistry*,
toxicity Apoptosis Cell Line, Tumor Drug Carriers / chemistry* Folic Acid / chemistry* Humans Metal Nanoparticles / chemistry*, toxicity Microscopy, Confocal Platinum / chemistry* Povidone / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Drug Carriers; 59-30-3/Folic Acid; 7440-06-4/Platinum; 9003-39-8/Povidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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