Document Detail

Active stable maintenance functions in low copy-number plasmids of Gram-positive bacteria II. Post-segregational killing systems.
MedLine Citation:
PMID:  23829073     Owner:  NLM     Status:  In-Process    
Active support is needed for low copy-number plasmids to be stably maintained in bacterial cells. The mechanisms that fulfill this role are (i) partition systems (PAR) acting to separate plasmid molecules to daughter cells and (ii) toxin-andidote (TA) (post-segregational killing-PSK) systems which arrest cell growth until the plasmid reaches the correct copy-number or kill the cells that have not inherited the plasmid. Our knowledge of toxin-antidote systems comes mainly from studies on Gram-negative bacteria. However, some addiction systems of Gram-positive bacteria have been characterized in detail or recently identified. Altogether, they bring new interesting data on toxin-antidote functioning in bacteria.
Michał Dmowski; Grazyna Jagura-Burdzy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists     Volume:  62     ISSN:  1733-1331     ISO Abbreviation:  Pol. J. Microbiol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229003     Medline TA:  Pol J Microbiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
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