| Active search for chronic thromboembolic pulmonary hypertension does not appear indicated after acute pulmonary embolism. | |
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MedLine Citation:
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PMID: 20085846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life threatening but often, by pulmonary endarterectomy, curable disease. The incidence of CTEPH after an acute pulmonary embolism (PE) appears to be much higher than previously thought. Systematic follow-up of patients after PE might increase the number of diagnosed CTEPH patients. AIM: To study whether, compared to current clinical practice, a systematic search for CTEPH in patients after acute PE would increase the number of patients diagnosed with symptomatic, potentially treatable CTEPH. METHODS: Consecutive patients with a prior diagnosis of acute PE were presented with a questionnaire, designed to establish the presence of either new or worsened dyspnea after the acute PE episode. If so, patients were evaluated for the presence of CTEPH. RESULTS: PE patients (n=110; 56+/-18 years) were included after a median follow-up of three years. Overall mortality was 34% (37 patients); 1 patient had died due to CTEPH. In total 62 out of 69 questionnaires were returned; 23 patients reported new or worsened dyspnea related to the PE episode, and qualified for additional testing. In 2 patients, CTEPH was already diagnosed prior to this study. None of the remaining patients met the criteria for the diagnosis of CTEPH. The overall incidence of 2.7% (3/110; 95%CI 0.6-7.8%) is in agreement with earlier reported incidences. CONCLUSION: Our findings do not point to a role for a systematic search and pro-active approach towards patients with a recent history of pulmonary embolism to increase the number of patients diagnosed with potentially treatable CTEPH. |
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Authors:
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Sulaiman Surie; Nadine S Gibson; Victor E A Gerdes; Berto J Bouma; Berthe L F van Eck-Smit; Harry R Buller; Paul Bresser |
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Publication Detail:
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Type: Journal Article Date: 2010-01-20 |
Journal Detail:
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Title: Thrombosis research Volume: 125 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: e202-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pulmonology, Academical Medical Center Amsterdam, the Netherlands. s.surie@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Causality Comorbidity Female Humans Hypertension, Pulmonary / diagnosis*, epidemiology* Male Middle Aged Netherlands / epidemiology Prevalence Pulmonary Embolism / diagnosis*, epidemiology* Risk Assessment / methods Risk Factors |
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