Document Detail

Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease: immunohistochemical study.
MedLine Citation:
PMID:  10869266     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Remodeling of the coronary artery lesions in Kawasaki disease has been observed in longitudinal angiographic studies. However, mechanisms of such remodeling have not yet been elucidated. METHODS AND RESULTS: We examined formalin-fixed specimens of the coronary arteries immunohistochemically by using antibodies against vascular growth factors (GFs) and their receptors in 7 children with Kawasaki disease, 9 children with no coronary disease, and 3 adults with atherosclerosis. In the thickened intima at stenotic sites and at recanalized vessels with Kawasaki disease, extensive expression of vascular GFs, such as transforming GF-beta(1), platelet-derived GF-A, and basic fibroblast GF, was observed both within and surrounding smooth muscle cells. Vascular endothelial GF was observed within smooth muscle cells. Furthermore, all of these GFs were strongly expressed in the newly formed microvessels within the intima. In the thinned media, these GFs were focally and weakly expressed. In contrast, these GFs were expressed only in the media in the control children. In cases of adult atherosclerosis, GFs were expressed diffusely in the media but focally and weakly if at all in the intima. CONCLUSIONS: Active remodeling of the coronary artery lesions in Kawasaki disease continues in the form of luxuriant intimal proliferation and neoangiogenesis for several years after the onset of the disease. This process is distinct from adult-onset atherosclerosis.
A Suzuki; S Miyagawa-Tomita; K Komatsu; T Nishikawa; Y Sakomura; T Horie; M Nakazawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  101     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2935-41     Citation Subset:  AIM; IM    
Department of Pediatrics, Tokyo Teishin Hospital, Fujimi, Japan.
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MeSH Terms
Arteries / metabolism,  pathology
Arteriosclerosis / metabolism
Child, Preschool
Coronary Disease / metabolism
Coronary Thrombosis / metabolism
Coronary Vessels / metabolism,  pathology*
Endothelial Growth Factors / metabolism
Growth Substances / metabolism
Lymphokines / metabolism
Mucocutaneous Lymph Node Syndrome / metabolism,  pathology*
Muscle, Smooth, Vascular / metabolism
Receptors, Growth Factor / metabolism
Reference Values
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Growth Substances; 0/Lymphokines; 0/Receptors, Growth Factor; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors

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