Document Detail

Active expectant management in very early gestations complicated by premature rupture of the fetal membranes.
MedLine Citation:
PMID:  8169909     Owner:  NLM     Status:  MEDLINE    
Premature rupture of the membranes (PROM) in the previable gestation is frequently associated with fetal or neonatal death. Passive expectant management is successful in only a small minority of cases. Women presenting with PROM at < or = 27 weeks' gestation were treated with tocolysis and prophylactic antibiotics and delivered electively for lung maturity. The corrected perinatal survival was > 92%. The mean latency phase was 21.6 days (+/- 18.12 SD). Twenty-one percent of patients presented in labor; the mean latency phase for this subgroup was 14.4 (+/- 8.54) days. Nineteen patients (79%) had a latency phase > 7 days, and 14 (58%) had a latency phase > 14 days. Thirty-nine percent of infants required < 48 hours of mechanical ventilation. Six infants were delivered with intraventricular hemorrhage; in all cases it was grade 1 or 2. There were three (12.5%) postpartum infections and three septic neonates. Active expectant management using tocolysis and prophylactic antibiotics was associated with a prolonged latency phase, low infectious morbidity and good neonatal outcome.
S J Fortunato; S I Welt; M K Eggleston; E C Bryant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  39     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Wright State University, Dayton, Ohio.
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MeSH Terms
Ceftizoxime / therapeutic use*
Clinical Protocols
Decision Trees
Delivery, Obstetric / methods*
Drug Therapy, Combination
Fetal Membranes, Premature Rupture / complications*,  diagnosis,  therapy*
Fetal Monitoring
Fetal Organ Maturity
Gestational Age
Infant, Newborn
Infant, Premature*
Magnesium Sulfate / therapeutic use*
Pregnancy Outcome
Pregnancy Trimester, Second
Prospective Studies
Terbutaline / therapeutic use*
Reg. No./Substance:
23031-25-6/Terbutaline; 68401-81-0/Ceftizoxime; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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