Document Detail

'Active chronic visceral leishmaniasis' in HIV-1-infected patients demonstrated by biological and clinical long-term follow-up of 10 patients.
MedLine Citation:
PMID:  20500233     Owner:  NLM     Status:  In-Process    
OBJECTIVES: The aim of the study was to describe a new evolutionary form of visceral leishmaniasis observed in immunocompromised patients.
METHODS: We carried out long-term clinical and biological follow-up of 10 HIV-1/Leishmania-coinfected patients presenting numerous secondary visceral leishmaniasis episodes despite treatment, with the follow-up time ranging from 0.5 to 10 years.
RESULTS: Analysis of polymerase chain reaction (PCR) and blood culture results demonstrated continuous multiplication and circulation of parasites despite treatment, both during asymptomatic periods and during secondary visceral leishmaniasis episodes. This condition may be termed 'chronic' because of the presence of relapses over a period of several years and 'active' because of the continuous blood circulation of the parasite.
CONCLUSION: We wish to define 'active chronic visceral leishmaniasis' as a novel nosological entity observed in HIV-1/Leishmania-coinfected patients.
N Bourgeois; P Bastien; J Reynes; A Makinson; I Rouanet; L Lachaud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  HIV medicine     Volume:  11     ISSN:  1468-1293     ISO Abbreviation:  HIV Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897392     Medline TA:  HIV Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  670-3     Citation Subset:  IM    
Copyright Information:
© British HIV Association.
Laboratory of Parasitology-Mycology, University Hospital, Nîmes, University Montpellier I, Montpellier, Nîmes, France.
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