Document Detail


Active anti-paternal immunization does not affect the success of marsupial pregnancy.
MedLine Citation:
PMID:  3912504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Active anti-paternal immunization does not compromise pregnancy in eutherian mammals. However, in an earlier study in a marsupial, grafting with paternal skin appeared to have resulted in transient infertility. In the present study, by critically monitoring the breeding efficiency of tammar wallabies sensitized against their mate's transplantation antigens, we aimed to resolve the question of immunologically mediated infertility in marsupials. Eight experimental females received two full-thickness skin grafts from their prospective mate and eight controls grafts of their own skin. The experimental group were monitored for 30 reproductive cycles and produced 24 pouch young (PY), whereas the control animals produced 28 young from 33 cycles. Five of the 11 apparently non-fertile cycles were judged to be normal pregnancies where the young had failed to reach the pouch (cycle length less than 28 days; rapid plasma progesterone decline coincident with oestrus). True infertility was thus limited and, although occurring mainly in the male-skin grafted group (5 cycles), this was not significantly different (chi 2, P greater than 0.5) from the controls (1 cycle) and represented the effect of one very poor breeder. We conclude that allogeneic pregnancy in marsupials is not compromised by active anti-paternal immunization. Infertility observed here, and in the earlier study, reflected disturbance of breeding owing to handling of the animals or the poor reproductive efficiency of individual animals in small experimental groups.
Authors:
J C Rodger; T P Fletcher; C H Tyndale-Biscoe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  8     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-04-02     Completed Date:  1986-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Immunization, Passive*
Macropodidae / immunology*
Male
Marsupialia / immunology*
Pregnancy
Pregnancy, Animal*
Progesterone / blood
Skin Transplantation*
Transplantation, Autologous
Transplantation, Homologous
Chemical
Reg. No./Substance:
57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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