| Active Ca2+ reabsorption in the proximal tubule of the rat kidney. Dependence on sodium- and buffer transport. | |
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MedLine Citation:
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PMID: 986634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the stop flow microperfusion technique with simultaneous capillary perfusion the rate active Ca2+ reabsorption was evaluated by measuring the static head electrochemical potential difference as well as the permeability of the tubular wall for Ca2+ ions. Under control conditions the active Ca2+ transport was calculated to be 3.35 X 10(-13) mol/cm - s. It declined toward zero if the ambient Na+ was replaced by choline or lithium. Parallel experiments in the golden hamster showed that active Ca2+ transport, vanished completely if active Na+ transport was blocked by ouabain (1 mM). These data indicate that the active Ca2+ reabsorption from the proximal tubule depends on the active reabsorption of Na2+ presumably via a Na+-Ca2+ countertransport at the contraluminal cell membrane. The static head electrochemical potential difference of Ca2+ is the same in late and early proximal tubules. It is also not affected by the presence of acetazolamide (10(-4) M) by the absence of bicarbonate or glycodiazine buffer or by the absence or presence of phosphate (2 mM). |
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Authors:
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K J Ullrich; G Rumrich; S Klöss |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 364 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1976 Aug |
Date Detail:
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Created Date: 1976-10-29 Completed Date: 1976-10-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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pharmacology Animals Bicarbonates / metabolism Biological Transport, Active Buffers Calcium / metabolism* Cell Membrane Permeability Choline / pharmacology Kidney Tubules, Proximal / metabolism* Lithium / pharmacology Male Ouabain / pharmacology Rats Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Buffers; 59-66-5/Acetazolamide; 62-49-7/Choline; 630-60-4/Ouabain; 7439-93-2/Lithium; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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