Document Detail

Activation of xanthine dehydrogenase during the prenatal period through L-thyroxine, thiourea and cycloheximide.
MedLine Citation:
PMID:  6414723     Owner:  NLM     Status:  MEDLINE    
Xanthine dehydrogenase activity in the liver of embryonic chicks has been shown to be inducible by L-thyroxine, thiourea, and cycloheximide. Results reported here indicate different mechanisms underlying the activation through L-thyroxine on the one hand, and through thiourea and cycloheximide on the other. Using hepatocyte suspension and homogenized liver, it has been shown that prenatal activation of xanthine dehydrogenase results in increased rate of uric acid formation from nucleic acids and purine derivatives, but not from amino acids.
J Wittmann; H Pruy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell differentiation     Volume:  13     ISSN:  0045-6039     ISO Abbreviation:  Cell Differ.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342640     Medline TA:  Cell Differ     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Cycloheximide / pharmacology*
Enzyme Activation / drug effects
Ketone Oxidoreductases / metabolism*
Kidney / metabolism
Liver / metabolism
Thiourea / pharmacology*
Thyroxine / pharmacology*
Time Factors
Uric Acid / biosynthesis
Xanthine Dehydrogenase / metabolism*
Reg. No./Substance:
62-56-6/Thiourea; 66-81-9/Cycloheximide; 69-93-2/Uric Acid; 7488-70-2/Thyroxine; EC Dehydrogenase; EC 1.2.-/Ketone Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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