Document Detail

Activation of virilizing adrenal rest tissues by excessive ACTH production. An unusual presentation of Nelson's syndrome.
MedLine Citation:
PMID:  7124773     Owner:  NLM     Status:  MEDLINE    
Nelson's syndrome occurs in 10 to 35 percent of patients treated for Cushing's disease by bilateral adrenalectomy and features an ACTH-producing pituitary tumor and hyperpigmentation. Cortisol-producing testicular tumors activated by markedly elevated ACTH levels have been described in male patients with Nelson's syndrome. We now describe a female patient with Nelson's syndrome who presented with virilization. Abdominal exploration revealed adrenal rest tumors in the paraovarian tissues and adrenal beds. Iodocholesterol scanning gave negative results. This case illustrates the need for follow-up study of patients with bilateral adrenalectomy for Cushing's disease and describes some of the unusual features these patients may present.
C Verdonk; C Guerin; E Lufkin; S F Hodgson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  73     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenal Cortex Hormones / secretion
Adrenal Rest Tumor / complications*,  diagnosis,  secretion
Adrenalectomy / adverse effects*
Middle Aged
Nelson Syndrome / diagnosis,  etiology*
Pituitary Neoplasms / etiology*
Virilism / etiology*
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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