| Activation of virilizing adrenal rest tissues by excessive ACTH production. An unusual presentation of Nelson's syndrome. | |
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MedLine Citation:
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PMID: 7124773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nelson's syndrome occurs in 10 to 35 percent of patients treated for Cushing's disease by bilateral adrenalectomy and features an ACTH-producing pituitary tumor and hyperpigmentation. Cortisol-producing testicular tumors activated by markedly elevated ACTH levels have been described in male patients with Nelson's syndrome. We now describe a female patient with Nelson's syndrome who presented with virilization. Abdominal exploration revealed adrenal rest tumors in the paraovarian tissues and adrenal beds. Iodocholesterol scanning gave negative results. This case illustrates the need for follow-up study of patients with bilateral adrenalectomy for Cushing's disease and describes some of the unusual features these patients may present. |
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Authors:
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C Verdonk; C Guerin; E Lufkin; S F Hodgson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 73 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 455-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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secretion Adrenal Rest Tumor / complications*, diagnosis, secretion Adrenalectomy / adverse effects* Adult Female Humans Middle Aged Nelson Syndrome / diagnosis, etiology* Pituitary Neoplasms / etiology* Virilism / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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