Document Detail

Activation of synthesis of hexacosenoic acid by sulfhydryl reagents in swine cerebral microsomes.
MedLine Citation:
PMID:  2839189     Owner:  NLM     Status:  MEDLINE    
The elongation of icosenoyl-CoA (20:1-CoA) in swine cerebral microsomes resulted in the synthesis of docosenoic acid (22:1) and tetracosenoic acid (24:1), but the synthesis of hexacosenoic acid (26:1) was negligible. In contrast, in the presence of sulfhydryl reagents (0.6 mM N-ethylmaleimide [NEM] or 0.3 mM p-chloromercuriphenylsulfonic acid [PCMPS]) the synthesis of 26:1 was remarkably enhanced. We suggest that the synthesis of 26:1 from 20:1-CoA was more enhanced by NEM or PCMPS as a result of activation of the condensation step in the elongation of 24:1 (intermediate) to 26:1.
T Saitoh; S Yoshida; M Takeshita
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry international     Volume:  16     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-08-03     Completed Date:  1988-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
Department of Biochemistry, Medical College of Oita, Japan.
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MeSH Terms
4-Chloromercuribenzenesulfonate / pharmacology
Brain / drug effects,  metabolism*
Ethylmaleimide / pharmacology
Fatty Acids / biosynthesis
Fatty Acids, Monounsaturated / biosynthesis*
Microsomes / drug effects,  metabolism
Sulfhydryl Reagents / pharmacology*
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Sulfhydryl Reagents; 128-53-0/Ethylmaleimide; 26444-07-5/1-hexacosenoic acid; 554-77-8/4-Chloromercuribenzenesulfonate

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