Document Detail

Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat.
MedLine Citation:
PMID:  18620003     Owner:  NLM     Status:  MEDLINE    
CONCLUSIONS: Activation of the submucosal plexus by cholecystokinin at the CCK(1) receptor accompanies stimulation of the dorsal vagal complex of the hindbrain and inhibition of food intake. Unlike the submucosal plexus, activation of the myenteric plexus is not necessary for cholecystokinin's influence on the dorsal vagal complex and food intake. The lack of activation in the myenteric plexus after camostat stimulation, in contrast to nutrient releasers of CCK such as oleate, suggests that intestinal stimulants can either release different amounts of CCK or cause release of CCK from I cells with different molecular forms of CCK. This would suggest that CCK-8 is released by camostat and is not able to travel to the myenteric plexus while a more stable form of CCK such as CCK-58 can travel to this site that is further away from the I cell.
Shannon J Raboin; Joseph R Reeve; Marvis S Cooper; Gary M Green; Ayman I Sayegh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-06-23
Journal Detail:
Title:  Regulatory peptides     Volume:  150     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-11-14     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / pharmacology
Devazepide / pharmacology
Eating / drug effects*
Gabexate / analogs & derivatives*,  pharmacology
Gastrointestinal Tract / drug effects*,  metabolism
Hormone Antagonists / pharmacology
Models, Biological
Myenteric Plexus / metabolism*
Proto-Oncogene Proteins c-fos / metabolism
Rats, Sprague-Dawley
Receptors, Cholecystokinin / physiology
Solitary Nucleus / drug effects
Submucous Plexus / drug effects*,  metabolism
Vagus Nerve / drug effects
Grant Support
Reg. No./Substance:
0/Hormone Antagonists; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Cholecystokinin; 0FD207WKDU/camostat; 4V7M9137X9/Gabexate; 9011-97-6/Cholecystokinin; JE6P7QY7NH/Devazepide

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