Document Detail

Activation of the renin-angiotensin system by sodium nitroprusside in essential hypertension.
MedLine Citation:
PMID:  6199605     Owner:  NLM     Status:  MEDLINE    
We previously have demonstrated that the sympathetic nervous system is activated proportionately to the degree of vasodepression induced in hypertensive patients. In the present study, the role of the renin-angiotensin system in modulating the vasodepressor response to sodium nitroprusside was examined. Nine hospitalized hypertensive patients receiving a diuretic were given serially incremental doses of sodium nitroprusside over a dose range of 0.05-4.8 micrograms/kg/min with each dose being infused for 10 min. Mean arterial pressure (MAP), heart rate (HR), plasma renin activity (PRA), and plasma norepinephrine (NE) concentration were measured prior to and during each dose level of sodium nitroprusside. Stepwise increments in PRA were seen in each patient as the dose of sodium nitroprusside was increased. The increase in PRA was proportional to the increase in plasma NE concentration and to the decrease in MAP in each patient. However, considerable intersubject variation was seen in these relationships. When examined by multiple linear stepwise regression analysis, the degree of vasodepression was found to be dependent on the baseline blood pressure and baroreflex sensitivity (r = 0.97). However, increment in PRA was not an independent determinant of the vasodepressor response. Thus, the renin angiotensin system may not be a significant component of the acute homeostatic response to vasodepression in these patients.
A M Shepherd; W Pinkley; M S Lin; J L McNay; T K Keeton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-03-29     Completed Date:  1984-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Depression, Chemical
Ferricyanides / therapeutic use*
Heart Rate / drug effects
Hydrochlorothiazide / therapeutic use
Hypertension / drug therapy*
Middle Aged
Nitroprusside / therapeutic use*
Norepinephrine / blood
Pressoreceptors / drug effects
Renin-Angiotensin System / drug effects*
Grant Support
5 R23 AG03096-03/AG/NIA NIH HHS
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 58-93-5/Hydrochlorothiazide

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