Document Detail

Activation of the renal sympathetic nerve by leptin microinjection into the ventromedial hypothalamus in rats.
MedLine Citation:
PMID:  12929569     Owner:  NLM     Status:  MEDLINE    
Leptin produced in white adipose tissue activates sympathetic nerve activity via the ventromedial hypothalamus (VMH) within the central nervous system (CNS). Using an electrophysiological technique, we investigated whether direct microinjection of leptin into the VMH elevates renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. Microinjection of leptin (100 ng/microL) into the VMH caused significant activation of RSNA from 25 minutes after administration but no affect on BP. We concluded that leptin-induced elevation of RSNA is mediated via the VMH or its vicinity within the CNS.
Mamoru Tanida; Katsuya Nagai; Hidekazu Kaneko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  17     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-08-21     Completed Date:  2004-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
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MeSH Terms
Kidney / innervation*
Leptin / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Sympathetic Nervous System / drug effects,  physiology*
Ventromedial Hypothalamic Nucleus / drug effects,  physiology*
Reg. No./Substance:

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