Document Detail


Activation of the reaper gene during ectopic cell killing in Drosophila.
MedLine Citation:
PMID:  8948586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The product of the reaper (rpr) gene is required for programmed cell death in Drosophila. We examined rpr expression during ectopic cell deaths caused by ionizing radiation or aberrant development. In both instances, dramatic induction of rpr expression was observed. A genomic fragment upstream of rpr confers this regulatory behavior upon a lacZ reporter transgene. In a model cell culture system, conditional expression of REAPER is sufficient to induce massive apoptosis that can be prevented by the anti-apoptotic protein p35. Overall, these results suggest that diverse signals converge at, or upstream of, rpr-associated transcriptional regulatory elements that can function to initiate a common apoptotic pathway involving ICE-like protease activity.
Authors:
W Nordstrom; P Chen; H Steller; J M Abrams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental biology     Volume:  180     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-26     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235-9039, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Apoptosis* / radiation effects
Drosophila Proteins*
Drosophila melanogaster / embryology*,  genetics
Gene Expression Regulation, Developmental*
Genes, Reporter
Peptide Biosynthesis*
Promoter Regions, Genetic
Radiation, Ionizing
Regulatory Sequences, Nucleic Acid
Signal Transduction
Transcription, Genetic
Transfection
Grant Support
ID/Acronym/Agency:
AG12466/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/reaper protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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