| Activation of rat brain protein kinase C by lipid oxidation products. | |
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MedLine Citation:
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PMID: 3178815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unsaturated fatty acid components of membrane lipids are susceptible to oxidation in vitro and in vivo. The initial oxidation products are hydroperoxy fatty acids that are converted spontaneously or enzymatically to a variety of products. Hydroperoxy derivatives of oleic, linoleic, or arachidonic acids stimulate the activity of protein kinase C (PKC) purified from rat brain. The hydroperoxy acids satisfy the requirement of PKC for phospholipid (e.g., phosphatidylserine). Activation is observed in the presence or absence of 1 mM Ca2+. Reduction of the hydroperoxides to alcohols or dehydration of the hydroperoxides to ketones increases the Ka for activation three- to fourfold but does not significantly reduce the maximal extent of PKC activation. The Ka's for activation by hydroperoxy acids are approximately half the values exhibited by the unoxidized fatty acids. Since oxidation of unsaturated fatty acids to hydroperoxides is the first event in lipid peroxidation, activation of PKC by hydroperoxy fatty acids may be an early cellular response to oxidative stress. |
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Authors:
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C A O'Brian; N E Ward; I B Weinstein; A W Bull; L J Marnett |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 155 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-21 Completed Date: 1988-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1374-80 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology* Calcium / metabolism Enzyme Activation Fatty Acids / pharmacology* Linoleic Acids / pharmacology Lipid Peroxides* Oxidation-Reduction Protein Kinase C / metabolism* Rats |
| Grant Support | |
ID/Acronym/Agency:
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CA 47479/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Linoleic Acids; 0/Lipid Peroxides; 23017-93-8/13-hydroperoxy-9,11-octadecadienoic acid; 7440-70-2/Calcium; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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