Document Detail

Activation of polyhydroxyalkanoates: functionalization and modification.
MedLine Citation:
PMID:  20036809     Owner:  NLM     Status:  MEDLINE    
Polyhydroxyalkanoates (PHAs) serve numerous bacteria as storage compounds. It is generally believed that under unbalanced growth conditions, n-hydroxyalkanoates are synthesized inside the bacterial cells, polymerized to polyesters, and densely packed in granules. In the absence of extracellular carbon, the internally stored PHAs are depolymerized and consequently metabolized to enable cell maintenance and reproduction. However, some bacteria exhibit growth associated production and degradation of PHAs as part of the cell sustainment. This natural production and degradation cycle indicates that PHAs possess biodegradability and may have biocompatibility properties. Since the discovery that some bacteria can incorporate 3-hydroxyalkanoates bearing functional groups from related substrates, research has led to structural diversification of PHAs by biosynthesis and chemical modifications. A commonly applied route for tailoring PHAs is their in situ functionalization by biosynthetically producing side chains with terminal double bonds followed by chemistry. Non-functionalized PHAs can also be activated by surface modification techniques. The resulting tailor-made structural and material properties have positioned polyhydroxyalkanoates well to contribute to the manufacturing of second and third generation biomaterials.
Philipp Hoefer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  15     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-04-23     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-121     Citation Subset:  IM    
Microbial and Enzymatic Technology Group, Bioprocess Center, Biotechnology Research Institute, National Research Council Canada, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada.
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MeSH Terms
Bacteria / metabolism*
Biocompatible Materials / chemical synthesis,  chemistry
Biosynthetic Pathways*
Molecular Structure
Polyhydroxyalkanoates / biosynthesis*,  chemical synthesis,  chemistry*
Tissue Engineering
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyhydroxyalkanoates

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