| Activation of platelets upon contact with a vitamin E-coated/non-coated surface. | |
| | |
MedLine Citation:
|
PMID: 23381644 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of this study was to determine the effects of a vitamin E-coated surface on platelet activation, focusing on the interactions among the vitamin E-coated surface, platelets and leukocytes. Platelet-rich plasma (PRP) or PRP containing leukocytes (LPRP) was used. No difference was observed in platelet activation between PRP and LPRP for a vitamin E-coated membrane, meaning that platelet activation triggered by leukocytes was suppressed in plasma coming in contact with a vitamin E-coated membrane, while the membrane itself directly induced platelet activation. The antioxidant capacity of the vitamin E-coated membrane in contact with PRP or LPRP was partially reduced, but sufficient residual capacity remained. The in vitro experiments using an oxidized vitamin E-coated surface revealed that P-selectin expression and superoxide anion production in the platelets and platelet adhesion were induced by contact with the oxidized vitamin E-coated surface. We conclude that contact with a vitamin E-coated surface reduces platelet activation mediated by superoxide anions, probably by reducing superoxide anions, but during the process of the reduction, the vitamin E-coated surface itself becomes oxidized, which again causes platelet activation. The beneficial effects of a vitamin E-coated dialyzer in respect of platelet activation were counteracted by the formation of oxidized vitamin E. |
| | |
Authors:
|
Hiroshi Tsukao; Kenichi Kokubo; Haruko Takahashi; Mina Nagasato; Takanori Endo; Naoto Iizuka; Toshihiro Shinbo; Minoru Hirose; Hirosuke Kobayashi |
Related Documents
:
|
10801334 - Phosphatidylinositol 4,5-bisphosphate domain inducers promote phospholipid transverse r... 23362044 - Ultrastructural characterization of surface-induced platelet activation on artificial m... 2505834 - Inhibition of phospholipid and platelet-dependent prothrombinase activity in the plasma... 3839684 - Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from do... 19630794 - Selective sorting of alpha-granule proteins. 3339274 - Pulmonary hypertension and edema induced by platelet-activating factor in isolated, per... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-5 |
Journal Detail:
|
Title: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs Volume: - ISSN: 1619-0904 ISO Abbreviation: J Artif Organs Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815648 Medline TA: J Artif Organs Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct use of formamides as amino group sources via C-N bond cleavage: a catalytic oxidative synthes...
Next Document: Migration of patients between five urban teaching hospitals in chicago.