| Activation of phosphofructokinase and pyruvate kinase by 6 phosphogluconate in chicken liver (Gallus domesticus): no evidence for a regulatory role. | |
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MedLine Citation:
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PMID: 6236117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphofructokinase and pyruvate kinase in crude extracts of chick liver were activated by 6 phosphogluconate at subsaturating concentrations of their respective substrates. The apparent Ka for phosphofructokinase was 0.79 mM and for pyruvate kinase 0.44 mM. Total pentose phosphate dehydrogenase activity was low in the livers of both fed and starved chicks. Hepatic 6 phosphogluconate concentration was too low to be measured accurately by a conventional spectrophotometric method. It is concluded that the concentration of 6 phosphogluconate is too low for it to have a role in the regulation of phosphofructokinase and pyruvate kinase activities in chicken liver. |
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Authors:
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D W Bannister |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of biochemistry Volume: 16 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-10-19 Completed Date: 1984-10-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 895-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Enzyme Activation Female Gluconates / pharmacology* Kinetics Liver / enzymology* Phosphofructokinase-1 / metabolism* Pyruvate Kinase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Gluconates; 921-62-0/6-phosphogluconate; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.1.40/Pyruvate Kinase |
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