Document Detail


Activation of phosphofructokinase and pyruvate kinase by 6 phosphogluconate in chicken liver (Gallus domesticus): no evidence for a regulatory role.
MedLine Citation:
PMID:  6236117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phosphofructokinase and pyruvate kinase in crude extracts of chick liver were activated by 6 phosphogluconate at subsaturating concentrations of their respective substrates. The apparent Ka for phosphofructokinase was 0.79 mM and for pyruvate kinase 0.44 mM. Total pentose phosphate dehydrogenase activity was low in the livers of both fed and starved chicks. Hepatic 6 phosphogluconate concentration was too low to be measured accurately by a conventional spectrophotometric method. It is concluded that the concentration of 6 phosphogluconate is too low for it to have a role in the regulation of phosphofructokinase and pyruvate kinase activities in chicken liver.
Authors:
D W Bannister
Related Documents :
23936117 - Regulation of flagellar biogenesis by a calcium dependent protein kinase in chlamydomon...
6319077 - Metabolism of glycerate-2,3-p2--v. histidine-specific reagents inactivate the phosphogl...
7104307 - Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl...
3677327 - Pyruvate kinase activity and response to allosteric effectors in rat erythrocytes and r...
18551177 - Diabetes alters contraction-induced mitogen activated protein kinase activation in the ...
24235147 - Cyclin-dependent kinase 5 (cdk5) regulates the function of clock protein by direct phos...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  16     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-19     Completed Date:  1984-10-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  895-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Enzyme Activation
Female
Gluconates / pharmacology*
Kinetics
Liver / enzymology*
Phosphofructokinase-1 / metabolism*
Pyruvate Kinase / metabolism*
Chemical
Reg. No./Substance:
0/Gluconates; 921-62-0/6-phosphogluconate; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.1.40/Pyruvate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Determination of circulating lymphocyte subpopulations in atopic dermatitis using monoclonal antibod...
Next Document:  The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in mic...