Document Detail

Activation of phosphofructokinase and pyruvate kinase by 6 phosphogluconate in chicken liver (Gallus domesticus): no evidence for a regulatory role.
MedLine Citation:
PMID:  6236117     Owner:  NLM     Status:  MEDLINE    
Phosphofructokinase and pyruvate kinase in crude extracts of chick liver were activated by 6 phosphogluconate at subsaturating concentrations of their respective substrates. The apparent Ka for phosphofructokinase was 0.79 mM and for pyruvate kinase 0.44 mM. Total pentose phosphate dehydrogenase activity was low in the livers of both fed and starved chicks. Hepatic 6 phosphogluconate concentration was too low to be measured accurately by a conventional spectrophotometric method. It is concluded that the concentration of 6 phosphogluconate is too low for it to have a role in the regulation of phosphofructokinase and pyruvate kinase activities in chicken liver.
D W Bannister
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  16     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-19     Completed Date:  1984-10-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  895-9     Citation Subset:  IM    
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MeSH Terms
Enzyme Activation
Gluconates / pharmacology*
Liver / enzymology*
Phosphofructokinase-1 / metabolism*
Pyruvate Kinase / metabolism*
Reg. No./Substance:
0/Gluconates; 921-62-0/6-phosphogluconate; EC; EC Kinase

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