| Activation of ornithine decarboxylase in epithelial cells of rat intestine. | |
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MedLine Citation:
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PMID: 7570589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal ornithine decarboxylase (ODC) is strongly induced by dietary amino acid and protein feeding. However, the consequence of this induction is unknown. In this study, we analyzed the relationship between intestinal ODC activity and DNA synthesis in villus and crypt cells of rat intestine. Single amino acid diets and protein diets stimulated ODC activity in villus cells, but not in crypt cells. However a 20% casein diet induced ODC activity and increased the putrescine concentration in villus and crypt cells. Administration of alpha-difluoromethylornithine, a suicide inhibitor of ODC, prevented both an increase in putrescine level and DNA synthesis in the crypt cells. Observations suggested that the induction of ODC is necessary to initiate DNA synthesis in rat intestinal epithelium. |
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Authors:
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F Takahashi; K Miyamoto; H Minami; E Takeda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tokushima journal of experimental medicine Volume: 42 ISSN: 0040-8875 ISO Abbreviation: Tokushima J. Exp. Med. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-11-08 Completed Date: 1995-11-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417356 Medline TA: Tokushima J Exp Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 11-5 Citation Subset: IM |
Affiliation:
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Department of Food Science, Shizuoka Eiwa College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division DNA / biosynthesis Enzyme Activation Epithelium / enzymology Intestines / enzymology* Male Ornithine Decarboxylase / metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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