Document Detail


Activation of normal genes in malignant cells: activation of chemotaxis in relation to other stages of normal differentiation in myeloid leukemia.
MedLine Citation:
PMID:  296588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetically differerent clones of myeloid leukemic cells have been used to study the activation of normal genes in these malignant cells by the normal physiological inducer of myeloid cell differentiation, the protein MGI. In appropriate clones, MGI induced the normal differentiation-associated property of chemotaxis to a variety of compounds including the steroid hormone dexamethasone. The induced cells could also distinguish among different steroids by chemotaxis, suggesting that there are specific membrane interaction sites for steroids. The sequence of differentiation in these cells was the formation of C3 and Fc rosettes leads to phagocytosis of these rosettes and chemotaxis leads to synthesis and secretion of lysozyme leads to mature macrophages or granulocytes. The use of appropriate mutants and the comparison of induction by MGI and dexamethasone has shown that chemotaxis to casein can be dissociated from: chemotaxis to dexamethasone, ATP, and bacterial factor; formation of C3 or Fc rosettes; phagocytosis of these rosettes; synthesis of lysozyme; and the formation of mature cells. It is suggested from this dissection of normal differentiation that there are different membrane changes for specific chemotaxis, formation of these rosettes, and their phagocytosis, and that induction of each of these properties requires activation of different genes.
Authors:
G Symonds; L Sachs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Somatic cell genetics     Volume:  5     ISSN:  0098-0366     ISO Abbreviation:  Somatic Cell Genet.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506054     Medline TA:  Somatic Cell Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
Chemotactic Factors / pharmacology
Chemotaxis
Clone Cells / immunology,  pathology
Complement C3 / biosynthesis
Dexamethasone / pharmacology
Genes*
Leukemia, Experimental / genetics
Leukemia, Myeloid / genetics*
Macrophages
Mice
Rosette Formation
Chemical
Reg. No./Substance:
0/Chemotactic Factors; 0/Complement C3; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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