Document Detail

Activation of natural killer cell function during interferon-alpha treatment of patients with condyloma acuminatum is predictive of clinical response.
MedLine Citation:
PMID:  3188977     Owner:  NLM     Status:  MEDLINE    
Patients with condyloma acuminatum were treated with subcutaneous injections of interferon alpha three times weekly for three weeks. Natural killer cell activity pre-treatment was the same for non-responders to interferon therapy as for responders. After two weeks of therapy, however, the natural killer cell activity of responders was significantly greater than that for non-responders. This difference in activity was also observed four weeks following therapy. It therefore appears that measurement of natural killer cell activity has value in predicting which patients with condyloma acuminatum will experience good clinical response to interferon therapy.
S K Tyring; R Cauda; V Ghanta; R Hiramoto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  2     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    1988 Apr-Jun
Date Detail:
Created Date:  1988-12-02     Completed Date:  1988-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Department of Microbiology, University of Texas Medical Branch, Galveston.
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MeSH Terms
Condylomata Acuminata / immunology,  therapy*
Interferon Type I / pharmacology*
Killer Cells, Natural / drug effects*,  immunology
Middle Aged
Grant Support
Reg. No./Substance:
0/Interferon Type I

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