| Activation of n-3 polyunsaturated fatty acids as oxime esters: A novel approach for their exclusive incorporation into the primary alcoholic positions of the glycerol moiety by lipase. | |
| | |
MedLine Citation:
|
PMID: 22850592 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A novel approach has been developed for activating the highly bioactive long-chain n-3 polyunsaturated fatty acids EPA and DHA as oxime esters and incorporating them exclusively to the end-positions of glycerol and enantiopure 1-O-alkylglycerols. The Candida antarctica lipase B was observed to display a superb regioselectivity when using the acetoxime esters of EPA and DHA as acyldonors under mild condition to keep acyl-migration side-reaction under complete control. Regiopure 1,3-diacylglycerols, 1-O-alkyl-3-acyl-sn-glycerols and their antipodes possessing EPA and DHA were afforded in very high purity and yields. |
| | |
Authors:
|
Carlos D Magnusson; Gudmundur G Haraldsson |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-28 |
Journal Detail:
|
Title: Chemistry and physics of lipids Volume: - ISSN: 1873-2941 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Science Institute, University of Iceland, Dunhaga 3, 107 Reykjavik, Iceland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optimized synthesis and characterization of N-acylethanolamines and O-acylethanolamines, important f...
Next Document: The importance of dye chemistry and TiCl(4) surface treatment in the behavior of Al(2)O(3) recombina...