| Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. | |
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MedLine Citation:
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PMID: 19765405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Curcumin, an active principle contained in rhizome of Curcuma longa, has been mentioned to show merit for diabetes through its anti-oxidative and anti-inflammatory properties. In the present study, we found that curcumin caused a concentration-dependent increase of glucose uptake into skeletal muscle isolated from Wistar rats. This action was inhibited by pirenzepine at concentration enough to block muscarinic M-1 cholinoceptor (M(1)-mAChR). In radioligand binding assay, the binding of [(3)H]-pirenzepine was also displaced by curcumin in a concentration-dependent manner. In the presence of inhibitors for PLC-PI3K pathway, either U73122 (phospholipase C inhibitor) or LY294002 (phosphoinositide 3-kinase inhibitor), curcumin-stimulated glucose uptake into skeletal muscle was markedly reduced. In Western blotting analysis, the membrane protein level of glucose transporter 4 (GLUT4) increased by curcumin was also reversed by blockade of M(1)-mAChR or PLC-PI3K pathway in a same manner. In conclusion, the obtained results suggest that curcumin can activate M(1)-mAChR at concentrations lower than to scavenge free radicals for increase of glucose uptake into skeletal muscle through PLC-PI3-kinase pathway. |
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Authors:
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Tse-Chou Cheng; Chian-Shiung Lin; Chih-Chieh Hsu; Li-Jen Chen; Kai-Chun Cheng; Juei-Tang Cheng |
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Publication Detail:
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Type: In Vitro; Journal Article Date: 2009-09-16 |
Journal Detail:
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Title: Neuroscience letters Volume: 465 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 238-41 Citation Subset: IM |
Affiliation:
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Department of Urology, Chi-Mei Medical Center, Yong Kang, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Curcumin / administration & dosage* Dose-Response Relationship, Drug Glucose / pharmacokinetics* Male Metabolic Clearance Rate / drug effects Muscle, Skeletal / drug effects, metabolism* Rats Rats, Wistar Receptor, Muscarinic M1 / agonists*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Muscarinic M1; 458-37-7/Curcumin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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