Document Detail


Activation of monocytes, T-lymphocytes and plasma inflammatory markers in angina patients.
MedLine Citation:
PMID:  10551265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the plasma levels of inflammatory markers and the degree of activation of peripheral blood monocytes and T-lymphocytes isolated from 12 unstable angina, 12 stable angina, and 12 normal subjects. In 20%-33% of patients, monocytes expressed high basal levels of IL-8, tissue factor, IL-1beta, and monocyte chemoattractant protein-1 mRNA. Furthermore, basal mRNA levels of these cytokines showed strong correlation with each other (p < 0.01 in all combination) but not with tumor necrosis factor-alpha or transforming growth factor-beta1. Plasma level of C-reactive protein was highest in the unstable angina patients (1.63+/-0.70 mg/l) and lowest in the control subjects (0.22+/-0.08 mg/l) (P = 0.03). We also observed a high correlation between C-reactive protein level and the occurrence of minor and major coronary events during 6 months of follow-up. Activation status of T-cells, assessed by the percentage of HLA-DR positive cells, was highest in the unstable angina patients (26.8+/-1.4%) compared with that in the control (14.7+/-1.2%) (P = 0.0053). Our data represent the first case showing that the circulating monocytes in angina patients are activated to a state express numerous proatherogenic cytokines. These results may help to diagnose angina patients according to the inflammatory markers and evaluate the prognosis of the disease.
Authors:
W H Lee; Y Lee; J R Kim; J A Chu; S Y Lee; J O Jung; J S Kim; S Kim; J D Seo; S S Rhee; J E Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  31     ISSN:  1226-3613     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-23     Completed Date:  1999-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
Clinical Research Center, Samsung Biomedical Research Institute, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / diagnosis,  immunology*
Angina, Unstable / diagnosis,  immunology*
Biological Markers / blood
C-Reactive Protein / analysis
Chemokine CCL2 / blood
Cytokines / blood*
Female
HLA-DR Antigens / immunology
Humans
Interleukins / blood
Lymphocyte Activation
Male
Middle Aged
Monocytes / metabolism*
RNA, Messenger / metabolism
T-Lymphocytes / metabolism*
Transforming Growth Factor beta / analysis
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chemokine CCL2; 0/Cytokines; 0/HLA-DR Antigens; 0/Interleukins; 0/RNA, Messenger; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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