Document Detail

Activation of membrane phospholipase A by guinea pig lymphotoxin (GLT).
MedLine Citation:
PMID:  312824     Owner:  NLM     Status:  MEDLINE    
The effect of GLT on target cells (L.P3 cells) labeled with radioactive fatty acids was examined. After incubation for 1 or 2 hr, no change in the survival ratio was observed, but radioactive fatty acid was released from phospholipids of the cells. When incubation was continued for 4 or 5 hr, the survival ratio was decreased with a concomitant increase of the radioactivity of triglyceride of the target cells and enhancement of calcium uptake into the target cells. These results could be explained by activation of membrane-bound phospholipase A after the binding of GLT to cell surface receptors.
Y Kobayashi; J I Sawada; T Osawa
Related Documents :
7906514 - Functional compartments of sulphatide metabolism in cultured living cells: evidence for...
10482394 - Melittin activates endogenous phospholipase d during cytolysis of human monocytic leuke...
7835594 - Fatty acid ethyl esters decrease human hepatoblastoma cell proliferation and protein sy...
19385994 - Cholesterol-dependent attachment of human respiratory cells by bordetella pertussis.
11890664 - Nuclear translocation of shp and visualization of interaction with hnf-4alpha in living...
23934044 - Effects of cd40 ligation combined with chemotherapy drugs on human breast cancer cell l...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  122     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-4     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Binding Sites
Calcium / metabolism
Cell Membrane / immunology
Cytotoxicity, Immunologic
Fatty Acids / metabolism
Guinea Pigs
Lymphotoxin-alpha / pharmacology*
Phospholipases / metabolism*
Reg. No./Substance:
0/Fatty Acids; 0/Lymphotoxin-alpha; 7440-70-2/Calcium; EC 3.1.-/Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Suppression of cytotoxic response to histoincompatible cells. II. Analysis of the role of two indepe...
Next Document:  Susceptibility of Friend virus antigen-modulated erythroleukemic cells to lysis by T lymphocytes fro...