Document Detail


Activation of membrane phospholipase A by guinea pig lymphotoxin (GLT).
MedLine Citation:
PMID:  312824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of GLT on target cells (L.P3 cells) labeled with radioactive fatty acids was examined. After incubation for 1 or 2 hr, no change in the survival ratio was observed, but radioactive fatty acid was released from phospholipids of the cells. When incubation was continued for 4 or 5 hr, the survival ratio was decreased with a concomitant increase of the radioactivity of triglyceride of the target cells and enhancement of calcium uptake into the target cells. These results could be explained by activation of membrane-bound phospholipase A after the binding of GLT to cell surface receptors.
Authors:
Y Kobayashi; J I Sawada; T Osawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  122     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Calcium / metabolism
Cell Membrane / immunology
Cytotoxicity, Immunologic
Fatty Acids / metabolism
Guinea Pigs
Lymphotoxin-alpha / pharmacology*
Phospholipases / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lymphotoxin-alpha; 7440-70-2/Calcium; EC 3.1.-/Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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