| Activation markers of peripheral blood mononuclear cells in late pregnancy and after delivery: a pilot study. | |
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MedLine Citation:
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PMID: 15647441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the putative shift of a Th1 to a Th2 immune response in pregnancy and its reversal post partum in healthy women and patients with rheumatoid arthritis (RA). METHODS: Peripheral blood mononuclear cells (PBMC) were examined by FACS analysis for the expression of activation markers CD25 and HLA-DR and chemokine receptors CXCR3 and CCR4 on CD4+ and CD8+ T cells in four healthy women and four patients with RA. Samples were analysed once in the third trimester and six and 12 weeks post partum. Eight healthy non-pregnant women served as controls. RESULTS: No reduction of CD25 and HLA-DR+ T cells occurred in the third trimester, but a significant increase was observed post partum in healthy women and an even greater increase in patients. Proportions of T cells expressing the CXCR3 or CCR4 marker were similar in patients and controls during pregnancy, whereas a significant increase occurred post partum. The ratio of CXCR3+ to CCR4+ cells remained unchanged during the observation period and did not differ significantly from that in non-pregnant controls. CONCLUSION: A shift from a Th1 to a Th2 immune response was not detected in the circulation of healthy pregnant women or pregnant patients. The significant increase of T cell activation after pregnancy warrants further investigation into the mechanisms of adjustment of the immune system post partum and its clinical correlates in rheumatic patients. |
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Authors:
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M Østensen; P Sicher; F Förger; P M Villiger |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 64 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-13 Completed Date: 2005-02-24 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 318-20 Citation Subset: IM |
Affiliation:
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Department of Rheumatology and Clinical Immunology, University Hospital, CH-3010 Bern, Switzerland. monika.oestensen@insel.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis, Rheumatoid / immunology* Female Flow Cytometry / methods Humans Immunity, Cellular Lymphocyte Activation* Pilot Projects Postpartum Period / immunology Pregnancy / immunology* Pregnancy Complications / immunology* T-Lymphocyte Subsets / immunology* Th1 Cells / immunology Th2 Cells / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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