Document Detail

Activation markers of peripheral blood mononuclear cells in late pregnancy and after delivery: a pilot study.
MedLine Citation:
PMID:  15647441     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the putative shift of a Th1 to a Th2 immune response in pregnancy and its reversal post partum in healthy women and patients with rheumatoid arthritis (RA). METHODS: Peripheral blood mononuclear cells (PBMC) were examined by FACS analysis for the expression of activation markers CD25 and HLA-DR and chemokine receptors CXCR3 and CCR4 on CD4+ and CD8+ T cells in four healthy women and four patients with RA. Samples were analysed once in the third trimester and six and 12 weeks post partum. Eight healthy non-pregnant women served as controls. RESULTS: No reduction of CD25 and HLA-DR+ T cells occurred in the third trimester, but a significant increase was observed post partum in healthy women and an even greater increase in patients. Proportions of T cells expressing the CXCR3 or CCR4 marker were similar in patients and controls during pregnancy, whereas a significant increase occurred post partum. The ratio of CXCR3+ to CCR4+ cells remained unchanged during the observation period and did not differ significantly from that in non-pregnant controls. CONCLUSION: A shift from a Th1 to a Th2 immune response was not detected in the circulation of healthy pregnant women or pregnant patients. The significant increase of T cell activation after pregnancy warrants further investigation into the mechanisms of adjustment of the immune system post partum and its clinical correlates in rheumatic patients.
M Østensen; P Sicher; F Förger; P M Villiger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  64     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-13     Completed Date:  2005-02-24     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  318-20     Citation Subset:  IM    
Department of Rheumatology and Clinical Immunology, University Hospital, CH-3010 Bern, Switzerland.
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MeSH Terms
Arthritis, Rheumatoid / immunology*
Flow Cytometry / methods
Immunity, Cellular
Lymphocyte Activation*
Pilot Projects
Postpartum Period / immunology
Pregnancy / immunology*
Pregnancy Complications / immunology*
T-Lymphocyte Subsets / immunology*
Th1 Cells / immunology
Th2 Cells / immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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