| Activation of lymphocyte proliferation by boronate-containing polymer immobilised on substrate: the effect of boron content on lymphocyte proliferation. | |
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MedLine Citation:
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PMID: 16888703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study demonstrates that boronic acid-containing polymers coated onto solid support function as synthetic mitogens for mouse lymphocytes. The polymer was synthesized by radical copolymerization of 3-acrylamidophenylboronic acid with dimethylacrylamide (poly(AAPBA-DMAA)). The boronic acid in the trigonal form in the copolymer activated lymphocytes, probably by crosslinkage to glycoprotein moieties on the plasma membrane surface, as in the case of lectin stimulation. A higher concentration of phenylboronic acid on the copolymer surface resulted in greater activation of lymphocytes, suggesting that the number of phenylboronic acid residues per unit area may be a crucial factor in lymphocyte proliferation. The proliferative response of lymphocytes was also affected by the surface wettability, probably due to a difference in the flexibility of polymer strands at the cell-polymer interface. |
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Authors:
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Hidenori Otsuka; Takeshi Ikeya; Teruo Okano; Kazunori Kataoka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-03 |
Journal Detail:
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Title: European cells & materials Volume: 12 ISSN: 1473-2262 ISO Abbreviation: Eur Cell Mater Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100973416 Medline TA: Eur Cell Mater Country: Scotland |
Other Details:
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Languages: eng Pagination: 36-43; discussion 36-43 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemistry*,
pharmacology* Animals Biocompatible Materials / chemistry*, pharmacology* Boronic Acids / analysis, chemistry*, pharmacology* Cell Proliferation / drug effects Hydrogen-Ion Concentration Lymphocyte Activation / drug effects* Male Mice Mitogens / chemistry, pharmacology Spleen / cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Biocompatible Materials; 0/Boronic Acids; 0/Mitogens; 0/poly(AAPBA-DMAA) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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