| Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices. | |
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MedLine Citation:
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PMID: 20582235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lecithin:cholesterol acyltransferase (LCAT) is an enzyme that first hydrolyzes the sn-2 position of phospholipids, preferentially a diacylphosphocholine, and then transfers the fatty acid to cholesterol to yield a cholesteryl ester. HDL ApoA-I is the principal catalytic activator for LCAT. Activity of LCAT on nascent or lipid-poor HDL particles composed of phospholipid, cholesterol and ApoA-I allows the maturation of HDL particles into lipid-rich spherical particles that contain a core of cholesteryl ester surrounded by phospholipid and ApoA-I on the surface. This article reviews the recent progress in elucidating structural aspects of the interaction between LCAT and ApoA-I. In the last decade, there has been considerable progress in understanding the structure of ApoA-I and the central helices 5, 6, and 7 that are known to activate LCAT. However, much less information has been forthcoming describing the 3D structure and conformation of LCAT required to catalyze two separate reactions within a single monomeric peptide. |
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Authors:
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Mary G Sorci-Thomas; Shaila Bhat; Michael J Thomas |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Clinical lipidology Volume: 4 ISSN: 1758-4302 ISO Abbreviation: - Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101502551 Medline TA: Clin Lipidol Country: - |
Other Details:
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Languages: ENG Pagination: 113-124 Citation Subset: - |
Affiliation:
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Department of Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1016, USA, Tel.: +1 336 716 2147, , msthomas@wfubmc.edu. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P01 HL049373-160009//NHLBI NIH HHS; R01 HL064163-08//NHLBI NIH HHS; P01 HL049373-160009//NHLBI NIH HHS; R01 HL064163-08//NHLBI NIH HHS |
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