Document Detail


Activation of the insular cortex during dynamic exercise in humans.
MedLine Citation:
PMID:  9306272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The insular cortex has been implicated as a region of cortical cardiovascular control, yet its role during exercise remains undefined. The purpose of the present investigation was to determine whether the insular cortex was activated during volitional dynamic exercise and to evaluate further its role as a site for regulation of autonomic activity. 2. Eight subjects were studied during voluntary active cycling and passively induced cycling. Additionally, four of the subjects underwent passive movement combined with electrical stimulation of the legs. 3. Increases in regional cerebral blood flow (rCBF) distribution were determined for each individual using single-photon emission-computed tomography (SPECT) co-registered with magnetic resonance (MR) images to define exact anatomical sites of cerebral activation during each condition. 4. The rCBF significantly increased in the left insula during active, but not passive cycling. There were no significant changes in rCBF for the right insula. Also, the magnitude of rCBF increase for leg primary motor areas was significantly greater for both active cycling and passive cycling combined with electrical stimulation compared with passive cycling alone. 5. These findings provide the first evidence of insular activation during dynamic exercise in humans, suggesting that the left insular cortex may serve as a site for cortical regulation of cardiac autonomic (parasympathetic) activity. Additionally, findings during passive cycling with electrical stimulation support the role of leg muscle afferent input towards the full activation of leg motor areas.
Authors:
J W Williamson; A C Nobrega; R McColl; D Mathews; P Winchester; L Friberg; J H Mitchell
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  503 ( Pt 2)     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM; S    
Affiliation:
University of Texas Southwestern Medical Center, Department of Physical Therapy, Dallas 75235, USA. jwill4@mednet.swmed.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling
Cerebral Cortex / blood supply,  physiology*,  radionuclide imaging
Cerebrovascular Circulation / physiology*
Electric Stimulation
Electromyography
Electrophysiology
Exercise / physiology*
Hemodynamics / physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Muscle, Skeletal / physiology
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Grant Support
ID/Acronym/Agency:
HL 08976-01/HL/NHLBI NIH HHS
Comments/Corrections
Erratum In:
J Physiol (Lond) 1997 Nov 1;504(Pt 3):764

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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