| Activation-induced deaminase: light and dark sides. | |
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MedLine Citation:
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PMID: 16861038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation-induced deaminase (AID) is required for class switch recombination (CSR) and somatic hypermutation (SHM), which are responsible for secondary diversification of antibodies in germinal centers. AID initiates these processes by deamination of cytosines on the immunoglobulin (Ig) locus, a potentially mutagenic activity. AID expression is restricted to germinal-center B cells, but the mechanisms that regulate its target specificity are not completely understood. Here, we review the most recent findings on the regulation of AID targeting and discuss how AID activity on non-Ig genes is relevant to the generation of chromosome translocations and to lymphomagenesis. |
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Authors:
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Virginia G de Yébenes; Almudena R Ramiro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-07-24 |
Journal Detail:
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Title: Trends in molecular medicine Volume: 12 ISSN: 1471-4914 ISO Abbreviation: Trends Mol Med Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2006-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: England |
Other Details:
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Languages: eng Pagination: 432-9 Citation Subset: IM |
Affiliation:
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DNA Hypermutation and Cancer Group, Spanish National Cancer Center (CNIO), Melchor Fernández Almagro 3, Madrid 28029, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Diversity / genetics B-Lymphocytes / enzymology Cell Transformation, Neoplastic Cytidine Deaminase / genetics, metabolism* Epigenesis, Genetic Gene Expression Regulation, Enzymologic Humans Immunoglobulin Class Switching / physiology Lymphoma / genetics Somatic Hypermutation, Immunoglobulin Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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