| Activation-induced cytidine deaminase structure and functions: A species comparative view. | |
| | |
MedLine Citation:
|
PMID: 21349283 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In the ten years since the discovery of activation-induced cytidine deaminase (AID) there has been considerable effort to understand mechanisms behind this enzymes ability to target and modify immunoglobulin genes leading to somatic hypermutation and class switch recombination. While the majority of research has focused on mouse and human models of AID function, work on other species, from lamprey to rabbit and sheep, has taught us much about the scope of functions of the AID mutator. This review takes a species-comparative approach to what has been learned about the AID mutator enzyme and its role in humoral immunity. |
| | |
Authors:
|
Vasco M Barreto; Brad G Magor |
Related Documents
:
|
21514963 - Children with hearing impairment - living with cochlear implants or hearing aids. 22405923 - The use of procedural knowledge in simple addition and subtraction problems. 18440523 - Infertility counseling for orthodox jewish couples. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
|
Title: Developmental and comparative immunology Volume: - ISSN: 1879-0089 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6 P-2780-156 Oeiras, Portugal, Tel: +351 21 4407932. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structural analysis of photodegraded lime wood by means of FT-IR and 2D IR correlation spectroscopy.
Next Document: Molecular cloning, expression and characterization of the functional domain of CTLA4 from the rhesus...