Document Detail

Activation-induced cell death in human T cells is a suicidal process regulated by cell density but superantigen induces T cell fratricide.
MedLine Citation:
PMID:  12576028     Owner:  NLM     Status:  MEDLINE    
Repeated ligation of the TCR results in apoptosis (activation-induced cell death; AICD). Superantigens such as Staphylococcal enterotoxin B (SEB) are particularly efficient at inducing AICD in T cells. We investigated whether apoptosis in human T cell subsets was due to fratricide (killing of neighboring cells) or suicide (cell autonomous death). AICD of Th1, Th2, Tc1, and Tc2 effector cells was dramatically enhanced at low cell densities and could be observed in single cell microcultures. AICD was unaffected by adhesion molecules or neighboring cells undergoing AICD, confirming the predominance of a suicidal mechanism. However, SEB was able to induce fratricidal apoptosis of type 1, but not type 2 cells. Fratricide was also observed when unstimulated T cells were exposed to activated Tc1 effector cells. Thus, AICD is tightly regulated to allow clonal T cell expansion and memory cell generation, but superantigens may subvert this process by allowing T cell fratricide.
Patricia Gorak-Stolinska; David M Kemeny; Alistair Noble
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular immunology     Volume:  219     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-02-10     Completed Date:  2003-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-107     Citation Subset:  IM    
Department of Immunology, Guy's, King's & St Thomas' School of Medicine, London, UK.
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MeSH Terms
Antibodies / pharmacology
Apoptosis / immunology*
Cell Count
Cells, Cultured
Enterotoxins / immunology*,  pharmacology
Staphylococcus aureus / immunology*
Superantigens / immunology*,  pharmacology
T-Lymphocyte Subsets / immunology,  pathology*
T-Lymphocytes, Cytotoxic / pathology
Th1 Cells / pathology
Th2 Cells / pathology
Reg. No./Substance:
0/Antibodies; 0/Enterotoxins; 0/Superantigens; 39424-53-8/enterotoxin B, staphylococcal

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