| Activation-induced cell death in human T cells is a suicidal process regulated by cell density but superantigen induces T cell fratricide. | |
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MedLine Citation:
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PMID: 12576028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Repeated ligation of the TCR results in apoptosis (activation-induced cell death; AICD). Superantigens such as Staphylococcal enterotoxin B (SEB) are particularly efficient at inducing AICD in T cells. We investigated whether apoptosis in human T cell subsets was due to fratricide (killing of neighboring cells) or suicide (cell autonomous death). AICD of Th1, Th2, Tc1, and Tc2 effector cells was dramatically enhanced at low cell densities and could be observed in single cell microcultures. AICD was unaffected by adhesion molecules or neighboring cells undergoing AICD, confirming the predominance of a suicidal mechanism. However, SEB was able to induce fratricidal apoptosis of type 1, but not type 2 cells. Fratricide was also observed when unstimulated T cells were exposed to activated Tc1 effector cells. Thus, AICD is tightly regulated to allow clonal T cell expansion and memory cell generation, but superantigens may subvert this process by allowing T cell fratricide. |
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Authors:
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Patricia Gorak-Stolinska; David M Kemeny; Alistair Noble |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular immunology Volume: 219 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2003-02-10 Completed Date: 2003-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 98-107 Citation Subset: IM |
Affiliation:
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Department of Immunology, Guy's, King's & St Thomas' School of Medicine, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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pharmacology Apoptosis / immunology* Cell Count Cells, Cultured Enterotoxins / immunology*, pharmacology Humans Staphylococcus aureus / immunology* Superantigens / immunology*, pharmacology T-Lymphocyte Subsets / immunology, pathology* T-Lymphocytes, Cytotoxic / pathology Th1 Cells / pathology Th2 Cells / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Enterotoxins; 0/Superantigens; 39424-53-8/enterotoxin B, staphylococcal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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