Document Detail


Activation of inactive kallikrein in the rat kidney during low sodium intake.
MedLine Citation:
PMID:  2610087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method was developed to measure the protease responsible for activation of inactive kallikrein in the rat kidney. The renal protease was evaluated by incubating the purified rat urinary inactive kallikrein with the renal cortical extract in the presence of cysteine at pH 5.0. The renal cortical extract produced a dose- and time-dependent activation of the inactive kallikrein. Levels of the renal protease responsible for activation of inactive kallikrein remained unchanged with dietary sodium restriction. On the other hand, urinary excretion of total, active, and inactive kallikrein increased significantly during low sodium intake, with no change in the ratio of active to total kallikrein. These results suggest that low sodium intake stimulates the biosynthesis of inactive kallikrein but not the activation of this kallikrein precursor in the kidney.
Authors:
M Takaoka; M Ohyama; M Nakamura; M Nishii; S Morimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  247B     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-09     Completed Date:  1990-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diet, Sodium-Restricted*
Enzyme Activation
Kallikreins / metabolism*,  urine
Kidney Cortex / enzymology*
Kinetics
Male
Rats
Rats, Inbred Strains
Reference Values
Chemical
Reg. No./Substance:
EC 3.4.21.-/Kallikreins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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