Document Detail


Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness.
MedLine Citation:
PMID:  12967923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single-neuron recording studies in non-human primates indicate that orbitofrontal cortex neurons represent the reward value of the sight, smell and taste of food, and even changes in the relative reward value, but provide no direct evidence on brain activity that is correlated with subjective reports of the pleasantness of food. In this fMRI investigation we report a significant correlation between the activation of a region of the human orbitofrontal cortex and the decrease in subjective pleasantness when a liquid food is eaten to satiety. Moreover, a cluster of voxels in the orbitofrontal cortex showed a decrease in its activation that was specific to the particular liquid food consumed in a meal, providing a neural correlate of sensory-specific satiety to a liquid whole food in humans. This sensory-specific reduction in activation of the orbitofrontal cortex correlating with subjective pleasantness is consistent with an important role for the orbitofrontal cortex in human emotion and motivation, and associated subjective states.
Authors:
M L Kringelbach; J O'Doherty; E T Rolls; C Andrews
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  13     ISSN:  1047-3211     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-11     Completed Date:  2003-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1064-71     Citation Subset:  IM    
Affiliation:
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Brain Mapping / methods*
Feeding Behavior / physiology*,  psychology
Frontal Lobe / physiology*
Humans
Male
Satiation / physiology
Smell / physiology
Taste / physiology*
Visual Cortex / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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